Novel insights into the antibiofilm activity of borneol, citral and their combination.

Wang, Wen
Faculteit Farmaceutische Wetenschappen
Vakgroep Farmaceutische Analyse
Gezamenlijk doctoraat
South China University of Technology in Guangzhou, China
Master of Fermentation Engineering, Henan University of Technology, 2013-2016; Bachelor of Biological Engineering (majoring in bio-pharmacy), Henan University of Technology, 2009-2013.
Academische graad
Doctor in de farmaceutische wetenschappen
Taal proefschrift
Vertaling titel
Nieuwe inzichten in de antibiofilmactiviteit van borneol, citral en hun combinatie.
Prof. dr. Tom Coenye, UGent-Farmaceutische Analyse - prof. dr. Jianyu Su, SCUT
Prof. dr. Aurélie Crabbé, UGent-Farmaceutische Analyse - Prof. dr. Paul Van der Meeren, UGent-Faculteit Bio-ingenieurswetenschappen - Prof. dr. Songqing, SCUT - Prof. dr. Zhenbo Xu, SCUT - Prof. dr. Yuhui Liao, Dermatology Hospital of Southern Medical University Guangzhou

Korte beschrijving

The problem of increased antibiotic resistance and improved environmental adaptability from bacteria has become a challenge for food safe and our public health, and this is of particular concern when bacteria form biofilms. Phytochemicals have shown great advantages and application prospects for the prevention of complex biofilms due to their excellent antibacterial properties, hard to develop resistance, and multi-target antibacterial strategies. Therefore, it is particularly important to understand their antibiofilm activity and mode of action against biofilm bacteria in different biofilm models, which is particularly important for realizing the control of pathogenic bacteria biofilm. Many different types of biofilms occur in food industry and clinical patients, but two of the most common ones are surface-attached biofilms and chronic biofilm aggregates that are found in pulmonary infections in cystic fibrosis patients and wound infections. Hence, the overall aim of this dissertation is to explore borneol and citral-based approaches for the prevention and treatment of different biofilms. This dissertation shows that combination of phytochemicals and encapsulation in Pickering emulsion are promising strategies to improve the efficacy of citral against biofilms in both in vitro and in vivo-like conditions. These capsules have potential applications as a general surface disinfectant as well as an antibiofilm agents for the treatment of lung infections in cystic fibrosis and wound infections.


Maandag 28 november 2022, 09:00
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